The
Properties Of Autograft Without the Associated Risks
Osteocel relies
on proprietary technology to produce a viable bone
matrix product containing stem cells. It is similar
to autograft not only because it is biologically active,
but because it is the only product available that provides
the three beneficial properties of autograft: osteoconduction,
osteoinduction, and osteogenesis. Osteocel allows surgeons
to offer benefits of these properties to their patients
without the discomfort and potential complications
of autograft harvesting, in addition to eliminating
the time spent on a secondary procedure. Processing
methods include selective immunodepletion such that
Osteocel contains a stem cell population of high cellular
purity for universal use.
Multipotentiality
 Stem cells contained in Osteocel are capable of differentiating
into various cell types and can respond to their environment
to differentiate into appropriate tissues as needed.
Every lot of Osteocel is tested for osteogenesis (bone
formation).
Viable Cell Content
The osteogenic potential arises from the stem cells in
Osteocel. Following processing of marrow-rich bone, release testing demonstrates
this potential. Every lot is tested to ensure that the cells are viable and
osteogenic.
Osteocel Purity
Processing dramatically reduces components that could stimulate
an immune response. The cellular identity is characterized with fluorescent
activated cell sorting (FACS).
Osteogenesis In Vivo
A posterolateral spinal fusion model in athymic rats demonstrated
bone growth and fusion following implantation of Osteocel. Radiographs showed
fusion while integration of Osteocel with the host bone and cellular repair
activity was evident on histology.
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